RT Journal Article
SR Electronic
T1 Immunoreactivity of transforming growth factor alpha in the normal adult gastrointestinal tract.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 628
OP 631
DO 10.1136/gut.33.5.628
VO 33
IS 5
A1 D M Thomas
A1 M M Nasim
A1 W J Gullick
A1 M R Alison
YR 1992
UL http://gut.bmj.com/content/33/5/628.abstract
AB The immunolocalisation of transforming growth factor alpha (TGF alpha) in the normal human oesophagus and the gastrointestinal tract was elucidated using two different antibodies - Ab2, a monoclonal antibody reacting with part of the human TGF alpha molecule, and 26T a rabbit affinity purified polyclonal antibody raised against part of the rat TGF alpha peptide. There have been conflicting reports on the distribution of this growth factor in the gut. The results clearly showed that this peptide regulatory factor is confined to the luminal surface and foveolae in the stomach, restricted to the villous epithelium in the small intestine, and in the colon was seen in the upper one third of the crypt. This pattern indicates that the distribution of this peptide regulatory factor is within the differentiated compartment and indicates a role in differentiation besides its well known proliferative effects.