RT Journal Article SR Electronic T1 Effect of acute cigarette smoking on gastric secretion. JF Gut JO Gut FD BMJ Publishing Group Ltd and British Society of Gastroenterology SP 1170 OP 1173 DO 10.1136/gut.33.9.1170 VO 33 IS 9 A1 J C Roxburgh A1 P F Whitfield A1 M Hobsley YR 1992 UL http://gut.bmj.com/content/33/9/1170.abstract AB The effects of smoking one cigarette on a plateau of submaximal gastric secretion induced by histamine acid phosphate (16 nmol kg-1 h-1 (0.005 mg kg-1 h-1)) were measured in eight normal volunteers and in eight duodenal ulcer subjects. The rate of secretion in both groups fell by 25% without any statistically significant change in pyloric loss or duodenogastric reflux. It is concluded that smoking reduces gastric secretion. The possibility that relative antral hypoacidity induced by regular smoking produces an increase in parietal cell mass via a feedback mechanism mediated by gastrin is discussed: such a mechanism would explain the previously reported positive correlation between maximal gastric secretion of acid and the total dose of cigarettes.