TY - JOUR T1 - Prevalence of peptic ulcer in Helicobacter pylori positive blood donors. JF - Gut JO - Gut SP - 309 LP - 312 DO - 10.1136/gut.35.3.309 VL - 35 IS - 3 AU - D Vaira AU - M Miglioli AU - P Mulè AU - J Holton AU - M Menegatti AU - M Vergura AU - G Biasco AU - R Conte AU - R P Logan AU - L Barbara Y1 - 1994/03/01 UR - http://gut.bmj.com/content/35/3/309.abstract N2 - This study aimed to determine the importance of raised antibodies to Helicobacter pylori in an asymptomatic population. A total of 128 asymptomatic blood donors who were seropositive for H pylori and consented to endoscopy were investigated. These subjects were from a population of 1010 blood donors screened for antibodies to H pylori. A questionnaire was completed to determine if any subjects had complained of symptoms, and they subsequently had endoscopy. Altogether 121 of 128 were positive for H pylori by histology and urease test and/or culture and all 121 had chronic active gastritis on histology. Twenty five of these subjects had peptic ulcer (20 duodenal, five gastric), a further 21 had erosive duodenitis, and two were found to have gastric cancer. H pylori associated peptic ulcer disease and duodenitis occur more frequently than previously recognised and this suggests that H pylori infection, even if asymptomatic, is of far greater clinical relevance than originally thought. ER -