RT Journal Article
SR Electronic
T1 Prevalence of peptic ulcer in Helicobacter pylori positive blood donors.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 309
OP 312
DO 10.1136/gut.35.3.309
VO 35
IS 3
A1 D Vaira
A1 M Miglioli
A1 P Mulè
A1 J Holton
A1 M Menegatti
A1 M Vergura
A1 G Biasco
A1 R Conte
A1 R P Logan
A1 L Barbara
YR 1994
UL http://gut.bmj.com/content/35/3/309.abstract
AB This study aimed to determine the importance of raised antibodies to Helicobacter pylori in an asymptomatic population. A total of 128 asymptomatic blood donors who were seropositive for H pylori and consented to endoscopy were investigated. These subjects were from a population of 1010 blood donors screened for antibodies to H pylori. A questionnaire was completed to determine if any subjects had complained of symptoms, and they subsequently had endoscopy. Altogether 121 of 128 were positive for H pylori by histology and urease test and/or culture and all 121 had chronic active gastritis on histology. Twenty five of these subjects had peptic ulcer (20 duodenal, five gastric), a further 21 had erosive duodenitis, and two were found to have gastric cancer. H pylori associated peptic ulcer disease and duodenitis occur more frequently than previously recognised and this suggests that H pylori infection, even if asymptomatic, is of far greater clinical relevance than originally thought.