TY - JOUR T1 - Analysis of Ha-ras 1 allele frequencies in hereditary non-polyposis colorectal cancer. JF - Gut JO - Gut SP - 382 LP - 384 DO - 10.1136/gut.36.3.382 VL - 36 IS - 3 AU - P Jeevaratnam AU - P J Browett AU - N S Van de Water AU - J R Jass Y1 - 1995/03/01 UR - http://gut.bmj.com/content/36/3/382.abstract N2 - Restriction enzyme digests of genomic DNA show multiple alleles of common, intermediate, and rare frequencies at the minisatellite locus of Ha-ras. It has been suggested that a higher frequency of rare alleles is associated with the presence of colorectal and other types of cancer. This study investigated the distribution of Ha-ras alleles in 40 members of hereditary non-polyposis colorectal carcinoma (HNPCC) families and in 34 cancer free subjects (spouses). There was no difference in rare allele frequency between the cancer group and cancer free group (chi2 = 0.25, not significant). ER -