PT  - JOURNAL ARTICLE
AU  - Jeevaratnam, P
AU  - Browett, P J
AU  - Van de Water, N S
AU  - Jass, J R
TI  - Analysis of Ha-ras 1 allele frequencies in hereditary non-polyposis colorectal cancer.
AID  - 10.1136/gut.36.3.382
DP  - 1995 Mar 01
TA  - Gut
PG  - 382--384
VI  - 36
IP  - 3
4099  - http://gut.bmj.com/content/36/3/382.short
4100  - http://gut.bmj.com/content/36/3/382.full
SO  - Gut1995 Mar 01; 36
AB  - Restriction enzyme digests of genomic DNA show multiple alleles of common, intermediate, and rare frequencies at the minisatellite locus of Ha-ras. It has been suggested that a higher frequency of rare alleles is associated with the presence of colorectal and other types of cancer. This study investigated the distribution of Ha-ras alleles in 40 members of hereditary non-polyposis colorectal carcinoma (HNPCC) families and in 34 cancer free subjects (spouses). There was no difference in rare allele frequency between the cancer group and cancer free group (chi2 = 0.25, not significant).