RT Journal Article
SR Electronic
T1 Analysis of Ha-ras 1 allele frequencies in hereditary non-polyposis colorectal cancer.
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 382
OP 384
DO 10.1136/gut.36.3.382
VO 36
IS 3
A1 P Jeevaratnam
A1 P J Browett
A1 N S Van de Water
A1 J R Jass
YR 1995
UL http://gut.bmj.com/content/36/3/382.abstract
AB Restriction enzyme digests of genomic DNA show multiple alleles of common, intermediate, and rare frequencies at the minisatellite locus of Ha-ras. It has been suggested that a higher frequency of rare alleles is associated with the presence of colorectal and other types of cancer. This study investigated the distribution of Ha-ras alleles in 40 members of hereditary non-polyposis colorectal carcinoma (HNPCC) families and in 34 cancer free subjects (spouses). There was no difference in rare allele frequency between the cancer group and cancer free group (chi2 = 0.25, not significant).