PT  - JOURNAL ARTICLE
AU  - A F Muller
AU  - A Maloney
AU  - D Jenkins
AU  - F Dowling
AU  - P Smith
AU  - E M Bessell
AU  - P J Toghill
TI  - Primary gastric lymphoma in clinical practice 1973-1992.
AID  - 10.1136/gut.36.5.679
DP  - 1995 May 01
TA  - Gut
PG  - 679--683
VI  - 36
IP  - 5
4099  - http://gut.bmj.com/content/36/5/679.short
4100  - http://gut.bmj.com/content/36/5/679.full
SO  - Gut1995 May 01; 36
AB  - This study assessed the presentation, treatment, and prognosis of primary gastric lymphoma in general hospital practice and its relation to infection with Helicobacter pylori. The number of patients that would on the current recommendations have been suitable for H pylori eradication therapy was also examined. All lymphomas were graded according to a standard classification of gut lymphoma into high and low grade disease. Forty five patients (mean age 65 years) were identified. The overall five year survival was 40% with a trend in favour of an improved prognosis for low grade and stage I disease. H pylori was present in 80%. Only one of 18 patients with a low grade mucosa associated lymphoid tissue tumour had mucosal disease alone, which responded to omeprazole and amoxycillin. All other patients had bulk disease. These patients were treated by surgery, chemotherapy or radiotherapy or a combination of these treatments. In district hospital practice, most cases of primary gastric lymphoma have bulk disease at presentation. Even in patients with low grade gastric lymphoma on histological examination, many on the current evidence would not be suitable for anti-H pylori therapy alone.