RT Journal Article
SR Electronic
T1 Effect of gastric acid suppressants on human gastric motility
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 243
OP 250
DO 10.1136/gut.42.2.243
VO 42
IS 2
A1 H P Parkman
A1 J-L C Urbain
A1 L C Knight
A1 K L Brown
A1 D M Trate
A1 M A Miller
A1 A H Maurer
A1 R S Fisher
YR 1998
UL http://gut.bmj.com/content/42/2/243.abstract
AB Background—The effect of histamine H2receptor antagonists on gastric emptying is controversial. Aims—To determine the effects of ranitidine, famotidine, and omeprazole on gastric motility and emptying. Patients and methods—Fifteen normal subjects underwent simultaneous antroduodenal manometry, electrogastrography (EGG), and gastric emptying with dynamic antral scintigraphy (DAS). After 30 minutes of fasting manometry and EGG recording, subjects received either intravenous saline, ranitidine, or famotidine, followed by another 30 minutes recording and then three hours of postprandial recording after ingestion of a radiolabelled meal. Images were obtained every 10–15 minutes for three hours to measure gastric emptying and assess antral contractility. Similar testing was performed after omeprazole 20 mg daily for one week. Results—Fasting antral phase III migrating motor complexes (MMCs) were more common after ranitidine (9/15 subjects, 60%), famotidine (12/15, 80%), and omeprazole (8/12, 67%) compared with placebo (4/14, 29%; p<0.05). Postprandially, ranitidine, famotidine, and omeprazole slowed gastric emptying, increased the amplitude of DAS contractions, increased the EGG power, and increased the antral manometric motility index. Conclusions—Suppression of gastric acid secretion with therapeutic doses of gastric acid suppressants is associated with delayed gastric emptying but increased antral motility.