@article {Rosenstock169, author = {S Rosenstock and L Kay and C Rosenstock and L P Andersen and O Bonnevie and T J{\o}rgensen}, title = {Relation between Helicobacter pylori infection and gastrointestinal symptoms and syndromes}, volume = {41}, number = {2}, pages = {169--176}, year = {1997}, doi = {10.1136/gut.41.2.169}, publisher = {BMJ Publishing Group}, abstract = {Background{\textemdash}Helicobacter pylori is a human pathogen that colonises the gastric mucosa and causes permanent gastric inflammation. Aims{\textemdash}To assess the symptoms of H pylori infection in an adult unselected population. Subjects{\textemdash}A random sample of 3589 adult Danes who were examined in 1982 and 1987 (n=2987). Methods{\textemdash}Abdominal symptoms within the preceding year were recorded at both attendances. Circulating IgG antibodies against H pylori in serum samples drawn in 1982 were measured by using in-house indirect enzyme linked immunosorbent assays (ELISA). Results{\textemdash}People with increased levels of IgG antibodies to H pylori were more likely than uninfected individuals to report heartburn (odds ratio (OR) = 1.26, 95\% confidence interval (CI) 1.03{\textendash}1.54) and abdominal pain characterised by daily length (OR = 1.33, 95\% CI 0.92{\textendash}1.91), nocturnal occurrence (OR = 1.62, 95\% CI 1.19{\textendash}2.19), spring aggravation (OR = 1.68, 95\% CI 0.70{\textendash}4.05), and no relation to meals (OR = 0.62, 95\% CI 0.43{\textendash}0.91) or stress (OR = 0.69, 95\% CI 0.50{\textendash}0.95). The inclusion of people with increased levels of IgG antibodies to H pylori, but without upper dyspepsia, at study entry significantly increased the likelihood of reporting upper dyspepsia at follow up (OR = 1.71, 95\% CI 1.24{\textendash}2.36). People with epigastric pain and increased levels of IgM antibodies to H pylori only indicative of acute H pylori infection were more likely to report nocturnal pain, heartburn, nausea, and vomiting. Conclusions{\textemdash}H pylori infection may precede the development of dyspepsia and is associated with a variety of gastrointestinal symptoms in people with no history of peptic ulcer disease.}, issn = {0017-5749}, URL = {https://gut.bmj.com/content/41/2/169}, eprint = {https://gut.bmj.com/content/41/2/169.full.pdf}, journal = {Gut} }