RT Journal Article
SR Electronic
T1 Glucagon-like peptide-1: a potent regulator of food intake in humans
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 81
OP 86
DO 10.1136/gut.44.1.81
VO 44
IS 1
A1 J-P Gutzwiller
A1 B Göke
A1 J Drewe
A1 P Hildebrand
A1 S Ketterer
A1 D Handschin
A1 R Winterhalder
A1 D Conen
A1 C Beglinger
YR 1999
UL http://gut.bmj.com/content/44/1/81.abstract
AB Background/Aims Studies in animals suggest a physiological role for glucagon-like peptide-1-(7–36)-amide (GLP-1) in regulating satiety. The role of GLP-1 in regulating food intake in man has, however, not been investigated.Subjects—Sixteen healthy male subjects were examined in a double blind placebo controlled fashion.Methods The effect of graded intravenous doses (0, 0.375, 0.75, and 1.5 pmol/kg/min) of synthetic human GLP-1 on food intake and feelings of hunger and satiety was tested in healthy volunteers.Results Graded GLP-1 infusions resulted in a dose dependent reduction in food intake (maximal inhibition 35%, p<0.001 vcontrol) and a similar reduction in calorie intake (32%; p<0.001). Fluid ingestion was also reduced by GLP-1 (18% reduction, p<0.01). No overt side effects were produced by GLP-1, but subjects experienced less hunger and early fullness in the period before a meal during GLP-1 infusion at the highest dose (p<0.05).Conclusions Intravenous infusions of GLP-1 decrease spontaneous food intake even at physiological plasma concentrations, implying an important role for GLP-1 in the regulation of the early satiety response in humans.GLP-1glucagon-like peptide-1CCKcholecystokinin