RT Journal Article
SR Electronic
T1 Scintigraphic validation of a magnetic resonance imaging method to study gastric emptying of a solid meal in humans
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 106
OP 111
DO 10.1136/gut.44.1.106
VO 44
IS 1
A1 C Feinle
A1 P Kunz
A1 P Boesiger
A1 M Fried
A1 W Schwizer
YR 1999
UL http://gut.bmj.com/content/44/1/106.abstract
AB Background We have previously used a magnetic resonance imaging (MRI) method to study gastric emptying of liquids. So far, however, it has not possible to assess solid gastric emptying with this technique.Aims To validate scintigraphically MRI as a method for measuring emptying of a mixed solid/liquid meal.Methods In eight healthy subjects, gastric emptying of a solid/liquid (SM) and a liquid meal (LM) of identical energy content and macronutrient composition was studied by scintigraphy and MRI for 120 minutes.Results MRI and scintigraphy agreed with respect to emptying profiles (intraclass correlation coefficient (RI) SM: 0.988, RI, LM: 0.917), t1/2 (SMMRI: 129 (9), SMScinti: 123 (11) minutes, NS; LMMRI: 100 (7), LMScinti: 110 (8) minutes, NS) and AUC (SMMRI: 8999 (232), SMScinti: 8788 (277) min%, NS; LMMRI: 8819 (368), LMScinti: 8891 (321) min%, NS).Conclusions MRI can be used to measure reliably gastric emptying not only of liquid but also of mixed solid/liquid meals in humans.MRImagnetic resonance imagingGd-DOTAgadolinium tetraazacyclododecane tetraacetic acidAUCarea under the curveRIintraclass correlation coefficient