PT  - JOURNAL ARTICLE
AU  - D Matzinger
AU  - L Degen
AU  - J Drewe
AU  - J Meuli
AU  - R Duebendorfer
AU  - N Ruckstuhl
AU  - M D'Amato
AU  - L Rovati
AU  - C Beglinger
TI  - The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans
AID  - 10.1136/gut.46.5.689
DP  - 2000 May 01
TA  - Gut
PG  - 689--694
VI  - 46
IP  - 5
4099  - http://gut.bmj.com/content/46/5/689.short
4100  - http://gut.bmj.com/content/46/5/689.full
SO  - Gut2000 May 01; 46
AB  - BACKGROUND AND AIMS The mechanism of intraduodenal fat induced inhibition of food intake is still unclear. Therefore, we tested the ability of duodenal fatty acids to suppress food intake at a lunchtime meal; in addition, we were interested to test if these effects were mediated by cholecystokinin (CCK) A receptors. SUBJECTS AND METHODS Three sequential double blind, three period crossover studies were performed in 12 healthy males each: (1) subjects received intraduodenal fat with or without 120 mg of tetrahydrolipstatin, an inhibitor of gastrointestinal lipases, or saline; (2) volunteers received intraduodenal long chain fatty acids, medium chain fatty acids, or saline; (3) subjects received long chain fatty acids or saline together with concomitant intravenous infusions of saline or loxiglumide, a specific CCK-A receptor antagonist. The effect of these treatments on food intake and feelings of hunger was quantified. RESULTS Intraduodenal fat perfusion significantly (p<0.05) reduced calorie intake. Inhibition of fat hydrolysis abolished this effect. Only long chain fatty acids significantly (p<0.05) decreased calorie intake, whereas medium chain fatty acids were ineffective. Infusion of loxiglumide abolished the effect of long chain fatty acids. CONCLUSIONS Generation of long chain fatty acids through hydrolysis of fat is a critical step for fat induced inhibition of food intake; the signal is mediated via CCK-A receptors.