RT Journal Article
SR Electronic
T1 Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 370
OP 376
DO 10.1136/gut.47.3.370
VO 47
IS 3
A1 P B Jeppesen
A1 B Hartmann
A1 J Thulesen
A1 B S Hansen
A1 J J Holst
A1 S S Poulsen
A1 P B Mortensen
YR 2000
UL http://gut.bmj.com/content/47/3/370.abstract
AB BACKGROUND The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying.AIM To investigate if GLP-1 and GLP-2 contribute to the positive effects of a preserved colon in short bowel patients by measuring circulating levels of GLP-1 and GLP-2 in seven ileum resected short bowel patients with a preserved colon and seven age and sex matched controls.METHODS GLP-1 and GLP-2 immunoreactivity was measured by specific radioimmunoassays in plasma collected at fasting and at regular intervals 180 minutes after a test meal.RESULTS Median (25–75%) fasting GLP-2 values were 72 (69–105) pmol/l versus 23 (19–27) pmol/l (p=0.001) and meal stimulated area under the curve was 21 078 (14 811–26 610) min×pmol/l versus 11 150 (7151–12 801) min×pmol/l (p=0.01) in short bowel patients with a preserved colon compared with control subjects. Fasting GLP-1 values were 10 (6–12) pmol/l versus 5 (3–5) pmol/l (p=0.01) and meal stimulated area under the curve was 3418 (2966–6850) min×pmol/l versus 2478 (1929–3199) min×pmol/l (p=0.04), respectively.CONCLUSION Ileum resected short bowel patients with a preserved colon had elevated fasting plasma concentrations of GLP-1 and GLP-2 and significantly larger meal stimulated areas under the curve compared with age and sex matched controls. Elevated GLP-1 and GLP-2 concentrations may contribute to the positive effects of a preserved colon on intestinal motility and functional adaptation in ileum resected short bowel patients.GLPglucagon-like peptideBMRbasal metabolic rate