TY - JOUR T1 - Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute<em>Campylobacter</em> enteritis and in post-dysenteric irritable bowel syndrome JF - Gut JO - Gut SP - 804 LP - 811 DO - 10.1136/gut.47.6.804 VL - 47 IS - 6 AU - R C Spiller AU - D Jenkins AU - J P Thornley AU - J M Hebden AU - T Wright AU - M Skinner AU - K R Neal Y1 - 2000/12/01 UR - http://gut.bmj.com/content/47/6/804.abstract N2 - BACKGROUND AND AIMS Post-dysenteric irritable bowel syndrome (PD-IBS) develops in up to 25% of patients followingCampylobacter enteritis. Our aim was to define the pathological basis of this subgroup of IBS.METHODS Twenty one patients (group 1) underwent serial rectal biopsy and gut permeability testing following acute Campylobacterenteritis as did 10 PD-IBS patients (group 2) and 12 asymptomatic controls.RESULTS In group 1, enteroendocrine cell (EC) numbers were markedly increased initially and at six and 12 weeks (p&lt;0.001) compared with controls. Gut permeability, as assessed by the lactulose/mannitol ratio, was significantly elevated, initially and at 12 weeks (p&lt;0.005). CD3, CD4, and CD8 lymphocyte counts in the lamina propria and intraepithelial lymphocytes (IEL) were significantly increased initially compared with controls. At visit 1, EC numbers were positively correlated with CD3 counts (r=0.6, p=0.01). At one year, seven subjects (five with persistent loose stools) had rectal biopsies which showed significantly elevated EC, CD3, and IEL counts. In group 2, EC and IEL counts were significantly increased compared with controls (p&lt;0.001), as was gut permeability (p&lt;0.01).CONCLUSION Increased EC, T lymphocytes, and gut permeability are acute changes followingCampylobacter enteritis which can persist for more than a year and may contribute to PD-IBS.PD-IBSpost-dysenteric irritable bowel syndromeECenteroendocrine cellIELintraepithelial lymphocyteDAB3′3 diaminobenzidine tetrahydrochloride5-HT5-hydroxytryptaminePYYpeptide YY ER -