TY - JOUR T1 - Short course acid suppressive treatment for patients with functional dyspepsia: results depend on<em>Helicobacter pylori</em>status JF - Gut JO - Gut SP - 473 LP - 480 DO - 10.1136/gut.47.4.473 VL - 47 IS - 4 AU - A L Blum AU - R Arnold AU - M Stolte AU - M Fischer AU - H R Koelz AU - the Frosch Study Group Y1 - 2000/10/01 UR - http://gut.bmj.com/content/47/4/473.abstract N2 - BACKGROUND AND AIMS Treatment of functional dyspepsia with acid inhibitors is controversial and it is not known if the presence ofHelicobacter pylori infection influences the response.METHODS After a complete diagnostic workup, 792 patients with functional dyspepsia unresponsive to one week of low dose antacid treatment were randomised to two weeks of treatment with placebo, ranitidine 150 mg, omeprazole 10 mg, or omeprazole 20 mg daily. Individual dyspeptic and other abdominal symptoms were evaluated before and after treatment according to H pylori status.RESULTS The proportions of patients considered to be in remission (intention to treat) at the end of treatment with placebo, ranitidine 150 mg, omeprazole 10 mg, and omeprazole 20 mg were, respectively, 42%, 50%, 48%, and 59% in the H pylori positive group and 66%, 73%, 64%, and 71% in the H pylori negative group. In H pyloripositive patients, the therapeutic gain over placebo was significant for omeprazole 20 mg (17.6%, 95% confidence intervals (CI) 4.2–31.0; p&lt;0.014 using the Bonferroni-adjusted p level of 0.017) but not for omeprazole 10 mg (6.8%, 95% CI −6.7–20.4) or ranitidine 150 mg (8.9%, 95% CI −4.2–21.9). There was no significant therapeutic gain from active treatment over placebo in H pylori negative patients. Complete disappearance of symptoms and improvement in quality of life also occurred most frequently with omeprazole 20 mg and was significant in both H pylori positive and H pylori negative groups. The six month relapse rate of symptoms requiring treatment was low (&lt;20%) in all groups.CONCLUSIONS Omeprazole 20 mg per day had a small but significant favourable effect on outcome in H pylori positive patients. The differential response in these patients may be explained by an enhanced antisecretory response in the presence of H pylori. The effect of weaker acid inhibition was unsatisfactory.QoLquality of lifeITTintention to treatPPper protocol ER -