PT - JOURNAL ARTICLE AU - A M Di Bisceglie TI - Combination therapy for hepatitis B AID - 10.1136/gut.50.4.443 DP - 2002 Apr 01 TA - Gut PG - 443--445 VI - 50 IP - 4 4099 - http://gut.bmj.com/content/50/4/443.1.short 4100 - http://gut.bmj.com/content/50/4/443.1.full SO - Gut2002 Apr 01; 50 AB - Hepatitis B virus is a major cause of morbidity and mortality worldwide. Effective therapies were first introduced in the mid-1980s but frequent and sometimes severe side effects limit their use. Combination therapy represents the future of treatment for chronic hepatitis B, probably consisting of two or more nucleoside analogues although interferon may form part of some combinations. New drugs acting by different antiviral mechanisms may be particularly potent in combination.