RT Journal Article SR Electronic T1 Combination therapy for hepatitis B JF Gut JO Gut FD BMJ Publishing Group Ltd and British Society of Gastroenterology SP 443 OP 445 DO 10.1136/gut.50.4.443 VO 50 IS 4 A1 A M Di Bisceglie YR 2002 UL http://gut.bmj.com/content/50/4/443.1.abstract AB Hepatitis B virus is a major cause of morbidity and mortality worldwide. Effective therapies were first introduced in the mid-1980s but frequent and sometimes severe side effects limit their use. Combination therapy represents the future of treatment for chronic hepatitis B, probably consisting of two or more nucleoside analogues although interferon may form part of some combinations. New drugs acting by different antiviral mechanisms may be particularly potent in combination.