PT  - JOURNAL ARTICLE
AU  - N J Talley
AU  - K Lauritsen
TI  - The potential role of acid suppression in functional dyspepsia: the BOND, OPERA, PILOT, and ENCORE studies
AID  - 10.1136/gut.50.suppl_4.iv36
DP  - 2002 May 01
TA  - Gut
PG  - iv36--iv41
VI  - 50
IP  - suppl 4
4099  - http://gut.bmj.com/content/50/suppl_4/iv36.short
4100  - http://gut.bmj.com/content/50/suppl_4/iv36.full
SO  - Gut2002 May 01; 50
AB  - Dyspepsia is a common condition in the general population but data are lacking on the benefits of effective acid inhibition with proton pump inhibitors in functional dyspepsia. The results of the large, randomised, double blind clinical trials, BOND and OPERA, the Scandinavian PILOT study, and a follow up study, ENCORE, are reviewed. BOND, OPERA, and PILOT aimed to address the question of whether effective acid inhibition with the proton pump inhibitor omeprazole relieves symptoms in patients with functional dyspepsia. ENCORE followed on from this, addressing the consequences of relieving symptoms in patients with functional dyspepsia once they are off therapy.