RT Journal Article
SR Electronic
T1 A novel case with germline p53 gene mutation having concurrent multiple primary colon tumours
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 304
OP 306
DO 10.1136/gut.52.2.304
VO 52
IS 2
A1 M Miyaki
A1 T Iijima
A1 M Ohue
A1 Y Kita
A1 T Hishima
A1 T Kuroki
A1 T Iwama
A1 T Mori
YR 2003
UL http://gut.bmj.com/content/52/2/304.abstract
AB During a search for causative genes in patients with concurrent multiple primary colon tumours, we found a novel case with a germline mutation of the p53 gene, from GCC (Ala) to GTC (Val) at codon 189. Of the six primary colon tumours that this patient had, one large advanced carcinoma exhibited a somatic p53 mutation and a somatic APC mutation, in addition to the germline p53 mutation. Two early carcinomas and three adenomas had somatic APC mutations but no somatic p53 mutation or loss of the p53 allele. K-ras-2 mutations were detected in an advanced carcinoma and an early carcinoma. The present results suggest that a patient with a certain type of germline p53 mutation is predisposed to concurrent multiple colon tumours. It is also suggested that in such a patient, a somatic APC mutation is involved in tumour formation and that an additional somatic p53 mutation contributes to tumour progression.