PT - JOURNAL ARTICLE AU - A H Lau AU - A W Thomson TI - Dendritic cells and immune regulation in the liver AID - 10.1136/gut.52.2.307 DP - 2003 Feb 01 TA - Gut PG - 307--314 VI - 52 IP - 2 4099 - http://gut.bmj.com/content/52/2/307.short 4100 - http://gut.bmj.com/content/52/2/307.full SO - Gut2003 Feb 01; 52 AB - Hepatic dendritic cells (DC) unquestionably play important roles in the induction and regulation of immune responses. Due to their paucity, functional characterisation of these important antigen presenting cells has been slow but use of DC growth factors (in particular GM-CSF and Flt3L) that markedly enhance their numbers has proved helpful in furnishing adequate study material. While there is growing evidence that DC function is affected in the pathogenesis of liver disease, most work to date has been performed on non-hepatic DC. Increasing knowledge of hepatic DC biology is likely to improve our understanding of disease pathogenesis and resistance to and therapy of liver disease.