PT  - JOURNAL ARTICLE
AU  - Schäppi, M G
AU  - Smith, V V
AU  - Milla, P J
AU  - Lindley, K J
TI  - Eosinophilic myenteric ganglionitis is associated with functional intestinal obstruction
AID  - 10.1136/gut.52.5.752
DP  - 2003 May 01
TA  - Gut
PG  - 752--755
VI  - 52
IP  - 5
4099  - http://gut.bmj.com/content/52/5/752.short
4100  - http://gut.bmj.com/content/52/5/752.full
SO  - Gut2003 May 01; 52
AB  - The diagnostic features and clinical course of three children (aged 1 month to 15 years) with severe functional intestinal obstruction and inflammation of the colonic lamina propria and myenteric plexus are described. The myenteric inflammatory infiltrate was eosinophil predominant with none of the immunological characteristics of lymphocytic ganglionitis. Neurones in the myenteric ganglia expressed the potent eosinophil chemoattractant interleukin 5. None responded to dietary exclusion but all three responded symptomatically to immunosuppression/anti-inflammatory treatments. Eosinophilic ganglionitis is associated with a pseudo-obstructive syndrome which is amenable to anti-inflammatory treatment.