RT Journal Article
SR Electronic
T1 Eosinophilic myenteric ganglionitis is associated with functional intestinal obstruction
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 752
OP 755
DO 10.1136/gut.52.5.752
VO 52
IS 5
A1 Schäppi, M G
A1 Smith, V V
A1 Milla, P J
A1 Lindley, K J
YR 2003
UL http://gut.bmj.com/content/52/5/752.abstract
AB The diagnostic features and clinical course of three children (aged 1 month to 15 years) with severe functional intestinal obstruction and inflammation of the colonic lamina propria and myenteric plexus are described. The myenteric inflammatory infiltrate was eosinophil predominant with none of the immunological characteristics of lymphocytic ganglionitis. Neurones in the myenteric ganglia expressed the potent eosinophil chemoattractant interleukin 5. None responded to dietary exclusion but all three responded symptomatically to immunosuppression/anti-inflammatory treatments. Eosinophilic ganglionitis is associated with a pseudo-obstructive syndrome which is amenable to anti-inflammatory treatment.