PT  - JOURNAL ARTICLE
AU  - G-T Ho
AU  - F M Moodie
AU  - J Satsangi
TI  - Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?
AID  - 10.1136/gut.52.5.759
DP  - 2003 May 01
TA  - Gut
PG  - 759--766
VI  - 52
IP  - 5
4099  - http://gut.bmj.com/content/52/5/759.short
4100  - http://gut.bmj.com/content/52/5/759.full
SO  - Gut2003 May 01; 52
AB  - The interface between luminal contents and intestinal epithelium constitutes the largest area of interaction between the host and the environment. There is now strong evidence that the gene product of the multidrug resistant pump (MDR) plays a critical role in host-bacterial interactions in the gastrointestinal tract and maintenance of intestinal homeostasis. This review highlights the efflux mechanism in the intestinal epithelium which is mediated by the multidrug resistant pump, also known as P-glycoprotein 170. Current studies promise to provide further insights into the contribution of the MDR1 gene in the pathogenesis of inflammatory and malignant disorders of the gastrointestinal tract.