PT  - JOURNAL ARTICLE
AU  - R C Fitzgerald
AU  - C Caldas
TI  - Clinical implications of E-cadherin associated hereditary diffuse gastric cancer
AID  - 10.1136/gut.2003.022061
DP  - 2004 Jun 01
TA  - Gut
PG  - 775--778
VI  - 53
IP  - 6
4099  - http://gut.bmj.com/content/53/6/775.1.short
4100  - http://gut.bmj.com/content/53/6/775.1.full
SO  - Gut2004 Jun 01; 53
AB  - Approximately 1–3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).