RT Journal Article
SR Electronic
T1 In vivo imaging with oligonucleotides for diagnosis and drug development
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP iv40
OP iv47
DO 10.1136/gut.52.suppl_4.iv40
VO 52
IS suppl 4
A1 B Tavitian
YR 2003
UL http://gut.bmj.com/content/52/suppl_4/iv40.abstract
AB Molecular imaging, the science that combines non-invasive in vivo imaging and molecular biology, has begun to use labelled oligonucleotides as radiotracers. Antisense oligonucleotides target gene expression at the RNA level, while aptamer oligonucleotides are designed to hit proteins of interest. Oligonucleotides for imaging cover a large range of applications, from the invention of new contrast agents for diagnosis to exquisite research tools for the development of new drugs.