TY - JOUR T1 - Association between <em>Helicobacter pylori</em> infection and interleukin 1β polymorphism predispose to CpG island methylation in gastric cancer JF - Gut JO - Gut SP - 595 LP - 597 DO - 10.1136/gut.2006.113258 VL - 56 IS - 4 AU - Annie On On Chan AU - Kent-Man Chu AU - Camy Huang AU - Kwok Fai Lam AU - Suet Yi Leung AU - Yun Wei Sun AU - Samuel Ko AU - Harry H Xia AU - Chi Hin Cho AU - Wai Mo Hui AU - Shiu Kum Lam AU - Asif Rashid Y1 - 2007/04/01 UR - http://gut.bmj.com/content/56/4/595.abstract N2 - Interleukin1β (IL1β) is upregulated in the presence of Helicobacter pylori infection.1 IL1β polymorphisms with T/T and T/C genotypes enhance IL1β production, and are associated with an increased risk of H pylori-induced hypochlorhydria2 and gastric cancer.3 The relationship between H pylori and CpG island methylation has been repeatedly reported.4–,6 It has been reported that IL1β can modulate CpG island methylation through activation of DNA methyltransferase and hence repress gene expression.7 We therefore hypothesised that patients with H pylori infection and IL1 polymorphism, by the production of IL1β, are predisposed to gastric cancer development through the CpG island methylation pathway.We obtained surgical specimens and their corresponding peripheral blood from 98 consecutive patients with gastric cancer admitted to Queen Mary Hospital, Hong Kong. This study was approved by the ethics committee. The … ER -