RT Journal Article
SR Electronic
T1 Green tea consumption and gastric cancer in Japanese: a pooled analysis of six cohort studies
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 1323
OP 1332
DO 10.1136/gut.2008.166710
VO 58
IS 10
A1 Inoue, M
A1 Sasazuki, S
A1 Wakai, K
A1 Suzuki, T
A1 Matsuo, K
A1 Shimazu, T
A1 Tsuji, I
A1 Tanaka, K
A1 Mizoue, T
A1 Nagata, C
A1 Tamakoshi, A
A1 Sawada, N
A1 Tsugane, S
A1 ,
YR 2009
UL http://gut.bmj.com/content/58/10/1323.abstract
AB Background: Previous experimental studies have suggested many possible anti-cancer mechanisms for green tea, but epidemiological evidence for the effect of green tea consumption on gastric cancer risk is conflicting.Objective: To examine the association between green tea consumption and gastric cancer.Methods: We analysed original data from six cohort studies that measured green tea consumption using validated questionnaires at baseline. Hazard ratios (HRs) in the individual studies were calculated, with adjustment for a common set of variables, and combined using a random-effects model.Results: During 2 285 968 person-years of follow-up for a total of 219 080 subjects, 3577 cases of gastric cancer were identified. Compared with those drinking <1 cup/day, no significant risk reduction for gastric cancer was observed with increased green tea consumption in men, even in stratified analyses by smoking status and subsite. In women, however, a significantly decreased risk was observed for those with consumption of ⩾5 cups/day (multivariate-adjusted pooled HR = 0.79, 95% confidence interval (CI) = 0.65 to 0.96). This decrease was also significant for the distal subsite (HR = 0.70, 95% CI = 0.50 to 0.96). In contrast, a lack of association for proximal gastric cancer was consistently seen in both men and women.Conclusions: Green tea may decrease the risk of distal gastric cancer in women.