TY - JOUR T1 - Dosing azathioprine in thiopurine <em>S</em>-methyltransferase deficient inflammatory bowel disease patients JF - Gut JO - Gut SP - 872 LP - 872 DO - 10.1136/gut.2007.145912 VL - 57 IS - 6 AU - L J J Derijks AU - R B van Helden AU - D W Hommes AU - P C Stokkers Y1 - 2008/06/01 UR - http://gut.bmj.com/content/57/6/872.1.abstract N2 - With great interest we read the article by Kaskas et al (Gut 2003;52:140–2) about safe treatment of thiopurine S-methyltransferase (TPMT) deficient Crohn’s disease patients with azathioprine (AZA). In this paper it is illustrated that TPMT-deficient patients can be successfully treated with very low doses of AZA (∼10% of standard initial dose). Unfortunately, this is not the case for all homozygous mutant TPMT allele carriers. This is demonstrated by the case report of an exceptional thiopurine S-methyltransferase deficient patient with inflammatory bowel disease who we identified recently. A 19-year-old man with ulcerative colitis who was attending the outpatient clinic was treated with … ER -