TY - JOUR T1 - The Authors' reply JF - Gut JO - Gut SP - 423 LP - 423 DO - 10.1136/gut.2010.226217 VL - 60 IS - 3 AU - Guy E Boeckxstaens AU - Tamira Klooker Y1 - 2011/03/01 UR - http://gut.bmj.com/content/60/3/423.2.abstract N2 - The Authors' reply We would like to thank Dr O'Sullivan for her positive comment1 on our paper recently published in Gut.2 We agree that the exact mechanism of action of ketotifen, either through mast cell stabilisation or H1 receptor blockade, needs further study. We tend to disagree, however, that we may have missed differences between patients with irritable bowel syndrome (IBS) and healthy subjects by … ER -