RT Journal Article
SR Electronic
T1 Endoscopic cyanoacrylate injection versus β-blocker for secondary prophylaxis of gastric variceal bleed: a randomised controlled trial
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 729
OP 735
DO 10.1136/gut.2009.192039
VO 59
IS 6
A1 Smruti Ranjan Mishra
A1 Barjesh Chander Sharma
A1 Ashish Kumar
A1 Shiv Kumar Sarin
YR 2010
UL http://gut.bmj.com/content/59/6/729.abstract
AB Background and aims Bleeding from gastric varices is often severe and difficult to manage. Endoscopic injection of gastric varices with cyanoacrylate is effective in prevention of rebleeding. The efficacy of β-blockers in secondary prophylaxis of gastric variceal bleed has not been well studied. A comparison of the efficacy of β-blocker treatment and cyanoacrylate injection for the prevention of gastric variceal rebleeding was carried out.Methods Patients with gastro-oesophageal varices type 2 (GOV2) with eradicated oesophageal varices or isolated gastric varices type 1 (IGV1) who had bled from gastric varices were randomised to cyanoacrylate injection (n=33) or β-blocker treatment (n=34). Baseline and follow-up upper gastrointestinal endoscopy and hepatic venous pressure gradient (HVPG) measurements were performed. Primary end points were gastric variceal rebleeding or death.Results The probability of gastric variceal rebleeding rate in the cyanoacrylate group was significantly lower than in the β-blocker group (15% vs 55%, p=0.004) and the mortality rate was lower (3% vs 25%, p=0.026) during a median follow-up of 26 months. The median baseline and follow-up HVPG in the cyanoacrylate group were 15 (10–23) and 17 (11–24) mm Hg (p=0.001) and for the β-blocker group 14 (11–24) and 13 (8–25) mm Hg (p=0.003). While no patient showed reduction of HVPG in the cyanoacrylate group, in the β-blocker group 12 of 28 (42%) patients were responders, of which 5 (41% of responders) bled. On multivariate analysis, treatment method, portal hypertensive gastropathy and size of the gastric varix >20 mm independently correlated with gastric variceal rebleeding. Gastric variceal rebleeding independently correlated with mortality.Conclusions Cyanoacrylate injection is more effective than β-blocker treatment for the prevention of gastric variceal rebleeding and improving survival.Clinical trial number NCT00888784.