TY - JOUR T1 - Therapeutic strategies for advanced neuroendocrine carcinomas of jejunum/ileum and pancreatic origin JF - Gut JO - Gut SP - 1009 LP - 1021 DO - 10.1136/gut.2009.204453 VL - 60 IS - 7 AU - Christoph J Auernhammer AU - Burkhard Göke Y1 - 2011/07/01 UR - http://gut.bmj.com/content/60/7/1009.abstract N2 - Multimodal treatment options for advanced gastroenteropancreatic neuroendocrine tumours (NET) of jejunum/ileum and of pancreatic origin are reviewed. Current topics being discussed are: European Neuroendocrine Tumour Society 2006/7, American Joint Cancer Committee/Union Internationale Contre le Cancer 2009 and WHO 2010 recommendations for grading and staging of NET; surgery of the primary tumour in distant metastasised disease; surgery of metastatic liver disease and impact on survival; somatostatin analogues for symptom control and for tumour control; selective internal radiation therapy with 90Y-microspheres as novel local ablative therapy in liver metastases; peptide receptor radionuclide therapy; novel chemotherapy regimens (eg, temozolomide) and novel targeted therapies (eg, sunitinib and everolimus). ER -