TY - JOUR T1 - Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition JF - Gut JO - Gut SP - 1094 LP - 1102 DO - 10.1136/gut.2010.225011 VL - 60 IS - 8 AU - Fränzel J B van Duijnhoven AU - H Bas Bueno-De-Mesquita AU - Miriam Calligaro AU - Mazda Jenab AU - Tobias Pischon AU - Eugène H J M Jansen AU - Jiri Frohlich AU - Amir Ayyobi AU - Kim Overvad AU - Anne Pernille Toft-Petersen AU - Anne Tjønneland AU - Louise Hansen AU - Marie-Christine Boutron-Ruault AU - Françoise Clavel-Chapelon AU - Vanessa Cottet AU - Domenico Palli AU - Giovanna Tagliabue AU - Salvatore Panico AU - Rosario Tumino AU - Paolo Vineis AU - Rudolf Kaaks AU - Birgit Teucher AU - Heiner Boeing AU - Dagmar Drogan AU - Antonia Trichopoulou AU - Pagona Lagiou AU - Vardis Dilis AU - Petra H M Peeters AU - Peter D Siersema AU - Laudina Rodríguez AU - Carlos A González AU - Esther Molina-Montes AU - Miren Dorronsoro AU - Maria-Jose Tormo AU - Aurelio Barricarte AU - Richard Palmqvist AU - Göran Hallmans AU - Kay-Tee Khaw AU - Kostas K Tsilidis AU - Francesca L Crowe AU - Veronique Chajes AU - Veronika Fedirko AU - Sabina Rinaldi AU - Teresa Norat AU - Elio Riboli Y1 - 2011/08/01 UR - http://gut.bmj.com/content/60/8/1094.abstract N2 - Objective To examine the association between serum concentrations of total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol, triglycerides, apolipoprotein A-I (apoA), apolipoprotein B and the incidence of colorectal cancer (CRC).Design Nested case–control study.Setting The study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort of more than 520 000 participants from 10 western European countries.Participants 1238 cases of incident CRC, which developed after enrolment into the cohort, were matched with 1238 controls for age, sex, centre, follow-up time, time of blood collection and fasting status.Main outcome measures Serum concentrations were quantitatively determined by colorimetric and turbidimetric methods. Dietary and lifestyle data were obtained from questionnaires. Conditional logistic regression models were used to estimate incidence rate ratios (RRs) and 95% CIs which were adjusted for height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish, alcohol, fibre and energy.Results After adjustments, the concentrations of HDL and apoA were inversely associated with the risk of colon cancer (RR for 1 SD increase of 16.6 mg/dl in HDL and 32.0 mg/dl in apoA of 0.78 (95% CI 0.68 to 0.89) and 0.82 (95% CI 0.72 to 0.94), respectively). No association was observed with the risk of rectal cancer. Additional adjustment for biomarkers of systemic inflammation, insulin resistance and oxidative stress or exclusion of the first 2 years of follow-up did not influence the association between HDL and risk of colon cancer.Conclusions These findings show that high concentrations of serum HDL are associated with a decreased risk of colon cancer. The mechanism behind this association needs further elucidation. ER -