TY - JOUR T1 - Local appendiceal dysbiosis: the missing link between the appendix and ulcerative colitis? JF - Gut JO - Gut SP - 635 LP - 636 DO - 10.1136/gutjnl-2011-300576 VL - 61 IS - 4 AU - X Roblin AU - C Neut AU - A Darfeuille-Michaud AU - J F Colombel Y1 - 2012/04/01 UR - http://gut.bmj.com/content/61/4/635.2.abstract N2 - We read with great interest the article by Swidsinski et al reporting on a possible link between acute appendicitis and a local invasion by Fusobacteria. Investigating sections of 70 appendixes with confirmed appendicitis using rRNA-based fluorescence in situ hybridisation, the authors found bacteria deeply infiltrating the appendix. Fusobacteria (mainly Fusobacterium nucleatum/necrophorum) were specific components of epithelial and submucosal infiltrates in 62% of patients and were not found in various controls. The presence of Fusobacteria correlated positively with the severity of appendicitis. Conversely, main faecal microbiota including Faecalibacterium prausnitzii groups were significantly decreased with an inverse relationship with the severity of the disease.1Altogether, these observations point to the presence … ER -