RT Journal Article SR Electronic T1 Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease JF Gut JO Gut FD BMJ Publishing Group Ltd and British Society of Gastroenterology SP 1721 OP 1727 DO 10.1136/gut.2011.242016 VO 60 IS 12 A1 Vincent Wai-Sun Wong A1 Grace Lai-Hung Wong A1 Gabriel Wai-Kwok Yip A1 Angeline Oi-Shan Lo A1 Jenny Limquiaco A1 Winnie Chiu-Wing Chu A1 Angel Mei-Ling Chim A1 Cheuk-Man Yu A1 Jun Yu A1 Francis Ka-Leung Chan A1 Joseph Jao-Yiu Sung A1 Henry Lik-Yuen Chan YR 2011 UL http://gut.bmj.com/content/60/12/1721.abstract AB Objective Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is associated with cardiovascular risk. The aim of this study was to determine the role of fatty liver in predicting coronary artery disease and clinical outcomes in patients undergoing coronary angiogram.Methods This was a prospective cohort study carried out in a University hospital. Consecutive patients who underwent coronary angiogram had ultrasound screening for fatty liver. Significant cardiovascular disease was defined as ≥50% stenosis in at least one coronary artery. The primary outcome was a composite end point comprising cardiovascular deaths, non-fatal myocardial infarction and the need for further coronary intervention during prospective follow-up.Results Among 612 recruited patients, 356 (58.2%) had fatty liver by ultrasonography, 318 (52.0%) had elevated serum alanine aminotransferase and 465 (76.0%) had significant coronary artery disease. Coronary artery disease occurred in 84.6% of patients with fatty liver and 64.1% of those without fatty liver (p<0.001). After adjusting for demographic and metabolic factors, fatty liver (adjusted OR 2.31; 95% CI 1.46 to 3.64) and alanine aminotransferase level (adjusted OR 1.01; 95% CI 1.00 to 1.02) remained independently associated with coronary artery disease. At a mean follow-up of 87±22 weeks, 30 (10.0%) patients with fatty liver and 18 (11.0%) patients without fatty liver reached the composite clinical end point (p=0.79).Conclusions In patients with clinical indications for coronary angiogram, fatty liver is associated with coronary artery disease independently of other metabolic factors. However, fatty liver cannot predict cardiovascular mortality and morbidity in patients with established coronary artery disease.