TY - JOUR T1 - Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study JF - Gut JO - Gut SP - 1764 LP - 1770 DO - 10.1136/gutjnl-2012-303006 VL - 62 IS - 12 AU - Dominique S Michaud AU - Jacques Izard AU - Charlotte S Wilhelm-Benartzi AU - Doo-Ho You AU - Verena A Grote AU - Anne Tjønneland AU - Christina C Dahm AU - Kim Overvad AU - Mazda Jenab AU - Veronika Fedirko AU - Marie Christine Boutron-Ruault AU - Françoise Clavel-Chapelon AU - Antoine Racine AU - Rudolf Kaaks AU - Heiner Boeing AU - Jana Foerster AU - Antonia Trichopoulou AU - Pagona Lagiou AU - Dimitrios Trichopoulos AU - Carlotta Sacerdote AU - Sabina Sieri AU - Domenico Palli AU - Rosario Tumino AU - Salvatore Panico AU - Peter D Siersema AU - Petra HM Peeters AU - Eiliv Lund AU - Aurelio Barricarte AU - José-María Huerta AU - Esther Molina-Montes AU - Miren Dorronsoro AU - J Ramón Quirós AU - Eric J Duell AU - Weimin Ye AU - Malin Sund AU - Björn Lindkvist AU - Dorthe Johansen AU - Kay-Tee Khaw AU - Nick Wareham AU - Ruth C Travis AU - Paolo Vineis AU - H Bas Bueno-de-Mesquita AU - Elio Riboli Y1 - 2013/12/01 UR - http://gut.bmj.com/content/62/12/1764.abstract N2 - Objective Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a twofold higher risk of pancreatic cancer than individuals with lower levels of these antibodies (OR 2.14; 95% CI 1.05 to 4.36; >200 ng/ml vs ≤200 ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified two groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45% lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR 0.55; 95% CI 0.36 to 0.83). Conclusions Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response. ER -