RT Journal Article
SR Electronic
T1 Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 1764
OP 1770
DO 10.1136/gutjnl-2012-303006
VO 62
IS 12
A1 Dominique S Michaud
A1 Jacques Izard
A1 Charlotte S Wilhelm-Benartzi
A1 Doo-Ho You
A1 Verena A Grote
A1 Anne Tjønneland
A1 Christina C Dahm
A1 Kim Overvad
A1 Mazda Jenab
A1 Veronika Fedirko
A1 Marie Christine Boutron-Ruault
A1 Françoise Clavel-Chapelon
A1 Antoine Racine
A1 Rudolf Kaaks
A1 Heiner Boeing
A1 Jana Foerster
A1 Antonia Trichopoulou
A1 Pagona Lagiou
A1 Dimitrios Trichopoulos
A1 Carlotta Sacerdote
A1 Sabina Sieri
A1 Domenico Palli
A1 Rosario Tumino
A1 Salvatore Panico
A1 Peter D Siersema
A1 Petra HM Peeters
A1 Eiliv Lund
A1 Aurelio Barricarte
A1 José-María Huerta
A1 Esther Molina-Montes
A1 Miren Dorronsoro
A1 J Ramón Quirós
A1 Eric J Duell
A1 Weimin Ye
A1 Malin Sund
A1 Björn Lindkvist
A1 Dorthe Johansen
A1 Kay-Tee Khaw
A1 Nick Wareham
A1 Ruth C Travis
A1 Paolo Vineis
A1 H Bas Bueno-de-Mesquita
A1 Elio Riboli
YR 2013
UL http://gut.bmj.com/content/62/12/1764.abstract
AB Objective Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a twofold higher risk of pancreatic cancer than individuals with lower levels of these antibodies (OR 2.14; 95% CI 1.05 to 4.36; >200 ng/ml vs ≤200 ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified two groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45% lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR 0.55; 95% CI 0.36 to 0.83). Conclusions Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response.