TY - JOUR T1 - MicroRNAs: new players in IBD JF - Gut JO - Gut SP - 504 LP - 513 DO - 10.1136/gutjnl-2014-307891 VL - 64 IS - 3 AU - R Kalla AU - N T Ventham AU - N A Kennedy AU - J F Quintana AU - E R Nimmo AU - A H Buck AU - J Satsangi Y1 - 2015/03/01 UR - http://gut.bmj.com/content/64/3/504.abstract N2 - MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications. ER -