RT Journal Article
SR Electronic
T1 Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 321
OP 329
DO 10.1136/gutjnl-2014-308351
VO 65
IS 2
A1 Palak J Trivedi
A1 Willem J Lammers
A1 Henk R van Buuren
A1 Albert Parés
A1 Annarosa Floreani
A1 Harry L A Janssen
A1 Pietro Invernizzi
A1 Pier Maria Battezzati
A1 Cyriel Y Ponsioen
A1 Christophe Corpechot
A1 Raoul Poupon
A1 Marlyn J Mayo
A1 Andrew K Burroughs
A1 Frederik Nevens
A1 Andrew L Mason
A1 Kris V Kowdley
A1 Ana Lleo
A1 Llorenç Caballeria
A1 Keith D Lindor
A1 Bettina E Hansen
A1 Gideon M Hirschfield
YR 2016
UL http://gut.bmj.com/content/65/2/321.abstract
AB Objective Hepatocellular carcinoma (HCC) is an infrequent yet critical event in primary biliary cirrhosis (PBC); however, predictive tools remain ill-defined. Our objective was to identify candidate risk factors for HCC development in patients with PBC.Design Risk factor analysis was performed in over 15 centres from North America and Europe spanning >40 years observation period using Cox proportional hazards assumptions, logistic regression, and Kaplan-Meier estimates.Results Of 4565 patients with PBC 123 developed HCC, yielding an incidence rate (IR) of 3.4 cases/1000 patient-years. HCC was significantly more common in men (p<0.0001), and on univariate analysis factors at PBC diagnosis associated with future HCC development were male sex (unadjusted HR 2.91, p<0.0001), elevated serum aspartate transaminase (HR 1.24, p<0.0001), advanced disease (HR 2.72, p=0.022), thrombocytopenia (HR 1.65, p<0.0001), and hepatic decompensation (HR 9.89, p<0.0001). As such, non-treatment with ursodeoxycholic acid itself was not associated with cancer development; however, 12-month stratification by biochemical non-response (Paris-I criteria) associated significantly with future risk of HCC (HR 4.52, p<0.0001; IR 6.6 vs 1.4, p<0.0001). Non-response predicted future risk in patients with early stage disease (IR 4.7 vs 1.2, p=0.005), advanced disease (HR 2.79, p=0.02; IR 11.2 vs 4.4, p=0.033), and when restricting the analysis to only male patients (HR 4.44, p<0.001; IR 18.2 vs 5.4, p<0.001). On multivariable analysis biochemical non-response remained the most significant factor predictive of future HCC risk (adjusted HR 3.44, p<0.0001).Conclusions This uniquely powered, internationally representative cohort robustly demonstrates that 12-month biochemical non-response is associated with increased future risk of developing HCC in PBC. Such risk stratification is relevant to patient care and development of new therapies.