TY - JOUR T1 - <em>Akkermansia muciniphila</em> and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology JF - Gut JO - Gut SP - 426 LP - 436 DO - 10.1136/gutjnl-2014-308778 VL - 65 IS - 3 AU - Maria Carlota Dao AU - Amandine Everard AU - Judith Aron-Wisnewsky AU - Nataliya Sokolovska AU - Edi Prifti AU - Eric O Verger AU - Brandon D Kayser AU - Florence Levenez AU - Julien Chilloux AU - Lesley Hoyles AU - MICRO-Obes Consortium AU - Marc-Emmanuel Dumas AU - Salwa W Rizkalla AU - Joel Doré AU - Patrice D Cani AU - Karine Clément Y1 - 2016/03/01 UR - http://gut.bmj.com/content/65/3/426.abstract N2 - Objective Individuals with obesity and type 2 diabetes differ from lean and healthy individuals in their abundance of certain gut microbial species and microbial gene richness. Abundance of Akkermansia muciniphila, a mucin-degrading bacterium, has been inversely associated with body fat mass and glucose intolerance in mice, but more evidence is needed in humans. The impact of diet and weight loss on this bacterial species is unknown. Our objective was to evaluate the association between faecal A. muciniphila abundance, faecal microbiome gene richness, diet, host characteristics, and their changes after calorie restriction (CR).Design The intervention consisted of a 6-week CR period followed by a 6-week weight stabilisation diet in overweight and obese adults (N=49, including 41 women). Faecal A. muciniphila abundance, faecal microbial gene richness, diet and bioclinical parameters were measured at baseline and after CR and weight stabilisation.Results At baseline A. muciniphila was inversely related to fasting glucose, waist-to-hip ratio and subcutaneous adipocyte diameter. Subjects with higher gene richness and A. muciniphila abundance exhibited the healthiest metabolic status, particularly in fasting plasma glucose, plasma triglycerides and body fat distribution. Individuals with higher baseline A. muciniphila displayed greater improvement in insulin sensitivity markers and other clinical parameters after CR. These participants also experienced a reduction in A. muciniphila abundance, but it remained significantly higher than in individuals with lower baseline abundance. A. muciniphila was associated with microbial species known to be related to health.Conclusions A. muciniphila is associated with a healthier metabolic status and better clinical outcomes after CR in overweight/obese adults. The interaction between gut microbiota ecology and A. muciniphila warrants further investigation.Trial registration number NCT01314690. ER -