TY - JOUR T1 - Colorectal cancer risk factors in patients with serrated polyposis syndrome: a large multicentre study JF - Gut JO - Gut SP - 1829 LP - 1837 DO - 10.1136/gutjnl-2015-309647 VL - 65 IS - 11 AU - Sabela Carballal AU - Daniel Rodríguez-Alcalde AU - Leticia Moreira AU - Luis Hernández AU - Lorena Rodríguez AU - Francisco Rodríguez-Moranta AU - Victoria Gonzalo AU - Luis Bujanda AU - Xavier Bessa AU - Carmen Poves AU - Joaquin Cubiella AU - Inés Castro AU - Mariano González AU - Eloísa Moya AU - Susana Oquiñena AU - Joan Clofent AU - Enrique Quintero AU - Pilar Esteban AU - Virginia Piñol AU - Francisco Javier Fernández AU - Rodrigo Jover AU - Lucía Cid AU - María López-Cerón AU - Miriam Cuatrecasas AU - Jorge López-Vicente AU - Maria Liz Leoz AU - Liseth Rivero-Sánchez AU - Antoni Castells AU - María Pellisé AU - Francesc Balaguer Y1 - 2016/11/01 UR - http://gut.bmj.com/content/65/11/1829.abstract N2 - Objective Serrated polyposis syndrome (SPS) is associated with an increased colorectal cancer (CRC) risk, although the magnitude of the risk remains uncertain. Whereas intensive endoscopic surveillance for CRC prevention is advised, predictors that identify patients who have high CRC risk remain unknown. We performed a multicentre nationwide study aimed at describing the CRC risk in patients with SPS and identifying clinicopathological predictors independently associated with CRC.Design From March 2013 through September 2014, patients with SPS were retrospectively recruited at 18 Spanish centres. Data were collected from medical, endoscopy and histopathology reports. Multivariate logistic regression was performed to identify CRC risk factors.Results In 296 patients with SPS with a median follow-up time of 45 months (IQR 26–79.7), a median of 26 (IQR 18.2–40.7) serrated polyps and 3 (IQR 1–6) adenomas per patient were detected. Forty-seven patients (15.8%) developed CRC at a mean age of 53.9±12.8, and 4 out of 47 (8.5%) tumours were detected during surveillance (cumulative CRC incidence 1.9%). Patients with >2 sessile serrated adenomas/polyps (SSA/Ps) proximal to splenic flexure and ≥1 proximal SSA/P with high-grade dysplasia were independent CRC risk factors (incremental OR=2, 95% CI 1.22 to 3.24, p=0.006). Patients with no risk factors showed a 55% decrease in CRC risk (OR=0.45, 95% CI 0.24 to 0.86, p=0.01).Conclusions Patients with SPS have an increased risk of CRC, although lower than previously published. Close colonoscopy surveillance in experienced centres show a low risk of developing CRC (1.9% in 5 years). Specific polyp features (SSA/P histology, proximal location and presence of high-grade dysplasia) should be used to guide clinical management. ER -