RT Journal Article
SR Electronic
T1 Development and validation of a histological index for UC
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 50
OP 58
DO 10.1136/gutjnl-2015-310393
VO 66
IS 1
A1 Mosli, Mahmoud H
A1 Feagan, Brian G
A1 Zou, Guangyong
A1 Sandborn, William J
A1 D'Haens, Geert
A1 Khanna, Reena
A1 Shackelton, Lisa M
A1 Walker, Christopher W
A1 Nelson, Sigrid
A1 Vandervoort, Margaret K
A1 Frisbie, Valerie
A1 Samaan, Mark A
A1 Jairath, Vipul
A1 Driman, David K
A1 Geboes, Karel
A1 Valasek, Mark A
A1 Pai, Rish K
A1 Lauwers, Gregory Y
A1 Riddell, Robert
A1 Stitt, Larry W
A1 Levesque, Barrett G
YR 2017
UL http://gut.bmj.com/content/66/1/50.abstract
AB Objective Although the Geboes score (GS) and modified Riley score (MRS) are commonly used to evaluate histological disease activity in UC, their operating properties are unknown. Accordingly, we developed an alternative instrument.Design Four pathologists scored 48 UC colon biopsies using the GS, MRS and a visual analogue scale global rating. Intra-rater and inter-rater reliability for each index and individual index items were measured using intraclass correlation coefficients (ICCs). Items with high reliability were used to develop the Robarts histopathology index (RHI). The responsiveness/validity of the RHI and multiple histological, endoscopic and clinical outcome measures were evaluated by analyses of change scores, standardised effect size (SES) and Guyatt's responsiveness statistic (GRS) using data from a clinical trial of an effective therapy.Results Inter-rater ICCs (95% CIs) for the total GS and MRS scores were 0.79 (0.63 to 0.87) and 0.80 (0.69 to 0.87). The correlation estimates between change scores in RHI and change score in GS and MRS were 0.75 (0.67 to 0.82) and 0.84 (0.79 to 0.88), respectively. The SES and GRS estimates for GS, MRS and RHI were: 1.87 (1.54 to 2.20) and 1.23 (0.97 to 1.50), 1.29 (1.02 to 1.56) and 0.88 (0.65 to 1.12), and 1.05 (0.79 to 1.30) and 0.88 (0.64 to 1.12), respectively.Conclusions The RHI is a new histopathological index with favourable operating properties.