TY - JOUR T1 - Influence of potassium-competitive acid blocker on the gut microbiome of <em>Helicobacter pylori</em>-negative healthy individuals JF - Gut JO - Gut SP - 1723 LP - 1725 DO - 10.1136/gutjnl-2016-313312 VL - 66 IS - 9 AU - Taketo Otsuka AU - Mitsushige Sugimoto AU - Ryo Inoue AU - Masashi Ohno AU - Hiromitsu Ban AU - Atsushi Nishida AU - Osamu Inatomi AU - Shunsuke Takahashi AU - Yuji Naito AU - Akira Andoh Y1 - 2017/09/01 UR - http://gut.bmj.com/content/66/9/1723.abstract N2 - We read with great interest two recent reports by Imhann et al1 and Jackson et al.2 Through large population-cohort study, each group revealed that gastric acid inhibition by long-term use of proton pump inhibitors (PPIs) changes the gut microbiome to predispose to enteric infection including Clostridium difficile (CD). Potassium-competitive acid blockers (P-CABs) have been reported to exert more potent gastric acid suppression than PPIs.3 ,4 The inhibitory effect of vonoprazan (TAK-438), a new P-CAB, on H+, K+-ATPase in vitro is approximately 400 times more potent than that of PPI (lansoprazole) (inhibitory concentration (IC)50 of vonoprazan 0.019 μM and lansoprazole 7.6 μM).5 We describe below that vonoprazan induces more complex alteration of the gut microbiome as compared with lansoprazole.We enrolled serum Helicobacter pylori IgG-negative healthy individuals to eliminate the influence of H. pylori infection on gastric acid secretion (see online supplementary table S1). The PPI group (n=11) took 30 mg of lansoprazole daily for 4 weeks, and the P-CAB group … ER -