TY - JOUR T1 - Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma JF - Gut JO - Gut SP - 380 LP - 388 DO - 10.1136/gutjnl-2017-315068 VL - 67 IS - 2 AU - Alexander Gerbes AU - Fabien Zoulim AU - Herbert Tilg AU - Jean-François Dufour AU - Jordi Bruix AU - Valérie Paradis AU - Riad Salem AU - Markus Peck-Radosavljevic AU - Peter R Galle AU - Tim F Greten AU - Jean-Charles Nault AU - Matias A Avila Y1 - 2018/02/01 UR - http://gut.bmj.com/content/67/2/380.abstract N2 - Hepatocellular carcinoma (HCC) ranks number three among the most frequent causes of death from solid tumors worldwide. With obesity and fatty liver diseases as risk factors on the rise, HCC represents an ever increasing challenge. While there is still no curative treatment for most patients numerous novel drugs have been proposed, but most ultimately failed in phase III trials. This manuscript targets therapeutic advances and most burning issues. Expert key point summaries and urgent research agenda are provided regarding risk factors, including microbiota, need for prognostic and predictive biomarkers and the equivocal role of liver biopsy. Therapeutic topics highlighted are locoregional techniques, combination therapies and the potential of immunotherapy. Finally the manuscript provides a critical evaluation of novel targets and strategies for personalized treatment of HCC. ER -