TY - JOUR T1 - Towards optimal pancreatic cyst fluid management: the need for standardisation JF - Gut JO - Gut DO - 10.1136/gutjnl-2018-317156 SP - gutjnl-2018-317156 AU - Giacomo Puppa AU - Yann Christinat AU - Thomas Alexander McKee Y1 - 2018/10/09 UR - http://gut.bmj.com/content/early/2018/10/09/gutjnl-2018-317156.abstract N2 - We read with interest the paper by Singhi et al.1 The authors prospectively assessed using targeted next-generation sequencing (NGS) 626 pancreatic cyst fluid (PCF) samples from 595 patients. They found that compared with Sanger sequencing, cytology and CEA, preoperative NGS for KRAS/GNAS mutations is highly sensitive for intraductal papillary mucinous neoplasms (IPMNs) and specific for mucinous pancreatic cysts (PCs).Moreover, alterations in TP53/PIK3/PTEN are significantly associated with advanced neoplasia facilitating decision-making for the management of these … ER -