RT Journal Article
SR Electronic
T1 Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 159
OP 171
DO 10.1136/gutjnl-2018-316451
VO 68
IS 1
A1 Neesse, Albrecht
A1 Bauer, Christian Alexander
A1 Öhlund, Daniel
A1 Lauth, Matthias
A1 Buchholz, Malte
A1 Michl, Patrick
A1 Tuveson, David A
A1 Gress, Thomas M
YR 2019
UL http://gut.bmj.com/content/68/1/159.abstract
AB Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote tumour progression, metastasis niche formation and therapeutic resistance. Intensive research of recent years has revealed an incredible heterogeneity and complexity of the different components of the TME, including cancer-associated fibroblasts, immune cells, extracellular matrix components, tumour vessels and nerves. It has been hypothesised that paracrine interactions between neoplastic epithelial cells and TME compartments may result in either tumour-promoting or tumour-restraining consequences. A better preclinical understanding of such complex and dynamic network systems is required to develop more powerful treatment strategies for patients. Scientific activity and the number of compelling findings has virtually exploded during recent years. Here, we provide an update of the most recent findings in this area and discuss their translational and clinical implications for basic scientists and clinicians alike.