TY - JOUR T1 - Association between proton pump inhibitors use and risk of gastric cancer in patients with GERD JF - Gut JO - Gut SP - 374 LP - 376 DO - 10.1136/gutjnl-2018-316057 VL - 68 IS - 2 AU - Yen-Chun Peng AU - Lam-Ru Huang AU - Cheng-Li Lin AU - Wan-Yun Hsu AU - Chi-Sen Chang AU - Hong-Zen Yeh AU - Chia-Hung Kao Y1 - 2019/02/01 UR - http://gut.bmj.com/content/68/2/374.abstract N2 - We read with interest the study by Cheung et al confirming the risk of proton pump inhibitors (PPIs) for gastric cancer regarding the patients after Helicobacter pylori (H. pylori) eradication with long-term PPIs use.1 Most concerns about the safety of PPIs pertain to the increased risk for enteric infections, fractures and nutritional deficiencies.2 To date, the association of PPIs use and risk of gastric cancer is still controversial in patients with gastro-oesophageal reflux diseases (GERD).For GERD, PPIs are the mainstay of treatment in the management of patients with acid-related disorders.3 Thus, patients with GERD usually take long-term PPIs,and possibly carry the risk of gastric cancer. In the present study, we performed a case–control study to investigate the association of PPIs use and risk of gastric cancer using data from a nationwide population database, the National Health Insurance Research Database (NHIRD) in Taiwan.4 This study also used a subdataset of the NHIRD, which comprises one million randomly sampled beneficiaries enrolled in the NHI programme in 2000 (Longitudinal Health Insurance Database … ER -