TY - JOUR T1 - Markers of non-coeliac wheat sensitivity in patients with myalgic encephalomyelitis/chronic fatigue syndrome JF - Gut JO - Gut SP - 377 LP - 378 DO - 10.1136/gutjnl-2018-316133 VL - 68 IS - 2 AU - Melanie Uhde AU - Alyssa C Indart AU - Xuechen B Yu AU - Sophie S Jang AU - Roberto De Giorgio AU - Peter H R Green AU - Umberto Volta AU - Suzanne D Vernon AU - Armin Alaedini Y1 - 2019/02/01 UR - http://gut.bmj.com/content/68/2/377.abstract N2 - We recently reported in Gut that non-coeliac wheat sensitivity (NCWS) is associated with a state of systemic immune activation in conjunction with a compromised intestinal epithelium.1 Patients with NCWS experience GI symptoms, most commonly including abdominal pain and bloating, as well as extraintestinal symptoms, among which fatigue, headache and cognitive difficulties feature prominently.1 2 A principal component analysis of the generated data from our study, including markers of antibody reactivity to wheat gluten, intestinal cell damage and systemic innate and adaptive immune responses to microbial components, found clustering of the patients and controls into discernible groups and demonstrated the potential utility of the identified biomarkers for identifying patients with NCWS.1 Extreme fatigue, in particular one that does not improve with rest, is a hallmark of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).3 Immune system abnormalities have been found to be associated with symptoms in a substantial number of patients with ME/CFS.4 5 Furthermore, many patients complain of GI symptoms of unknown aetiology. … ER -