TY - JOUR T1 - Is colonic propionate delivery a novel solution to improve metabolism and inflammation in overweight or obese subjects? JF - Gut JO - Gut SP - 1352 LP - 1353 DO - 10.1136/gutjnl-2019-318776 VL - 68 IS - 8 AU - Patrice D Cani Y1 - 2019/08/01 UR - http://gut.bmj.com/content/68/8/1352.abstract N2 - Increased intake of dietary fibre has been linked to beneficial impacts on health for decades. Strikingly, the exact mechanisms of action are not yet fully understood. Among the different families of fibres, prebiotics have gained attention mainly because of their capacity to selectively modulate the gut microbiota composition and promote health benefits.1 Prebiotics are fermented by gut bacteria into short-chain fatty acids (SCFA) such as acetate, butyrate and propionate, but multiple other metabolites have also been described.2 SCFAs have been connected with different physiological processes including the regulation of glucose and lipid metabolism but also energy, immunity and inflammation. Therefore, the gut microbiota has been suggested as a potential target to mitigate cardiometabolic disorders associated with obesity (for review, see ref 3).Among the different SCFAs, propionate has attracted the most attention because of its capacity to bind to specific receptors and trigger the secretion of gut peptides such as glucagon-like peptide-1 and peptide YY which are involved in the regulation of appetite and glucose metabolism.3 In addition, propionate has been found to enhance the development of regulatory T cells and to reduce the expansion of proinflammatory Th17 cells.4 Therefore, increasing the endogenous production of propionate or its delivery in the colon is an attractive solution to improve metabolic disorders.Pioneering work by Chambers and colleagues has shown that … ER -