TY - JOUR T1 - <em>Primum non nocere</em>: is faecal microbiota transplantation doing harm to patients with IBS? JF - Gut JO - Gut SP - 1722 LP - 1723 DO - 10.1136/gutjnl-2018-317277 VL - 68 IS - 9 AU - Paul Enck Y1 - 2019/09/01 UR - http://gut.bmj.com/content/68/9/1722.1.abstract N2 - A recent paper in this journal1 caught my attention: In a well-designed placebo-controlled trial of faecal microbiota transplantation (FMT) in patients with IBS, 12 days of blinded provision of the transplant or placebo in capsules improved symptoms in patients randomised to placebo significantly better than in patients receiving FMT, for IBS symptom severity at 3 and 6 months, and for IBS quality of life at 1, 3 and 6 months of follow-up. Patients receiving FMT showed sustained alterations of their microbiota, obviously unrelated to the symptom burden.Taking the effect of FMT on the gut microbiota in IBS aside (that has a scientific value by itself), these results not only imply that improvements seen with FMT in IBS in controlled2 … ER -